Most probiotics never reach your gut alive. DE111 is a spore-forming probiotic in a natural shell that survives stomach acid. In an ileostomy study it reached the small intestine within 3 hours and germinated to live cells by hour 6.
Survives stomach acid
Yes
No
Refrigeration needed
No
Yes
Shelf life at room temp
24 months
Days to weeks
Effective dose
1bn CFU/day
10 to 20bn CFU/day
Genome sequenced
Yes
Variable
Peer-reviewed evidence
Survives stomach acid, germinates in the gut within 3 hours.
Ileostomy study: DE111 spores measured at 6.4x10⁴ CFU/g in the ileum within 3 hours, rising to 9.7x10⁷ CFU/g by hour 6.
Colom J, et al. (2021). Frontiers in Microbiology.
Improves microbiome diversity in a placebo-controlled trial.
8-week RCT in healthy children. Alpha-diversity (Chao1) climbed in the DE111 group from baseline; no change in placebo.
Paytuví-Gallart A, et al. (2020). Beneficial Microbes, 11(7), 611 to 620.
Supports bowel regularity in adults with occasional GI irregularity.
90-day double-blind RCT in 50 adults. One capsule of 1x10⁹ CFU DE111 daily vs placebo.
Cuentas AM, et al. (2017). Clinical Trial NCT04083521.
Shifts immune cells toward an anti-inflammatory state.
4-week RCT in 44 adults at 1x10⁹ CFU/day. Downregulation of basal pro-inflammatory cell populations; stronger anti-inflammatory response to ex vivo LPS challenge.
Freedman KE, et al. (2021). Int. J. Molecular Sciences, 22(5), 2453.
FDA GRAS status. 24 months stable at room temperature.
DE111 holds Generally Recognized As Safe status (GRAS Notice 831, 2019). Viability maintained at 25C with virtually no CFU loss, no refrigeration required.
FDA GRAS Notice 831 (2019); ADM/Deerland DE111 Technical Data.
Studies reference the DE111 strain. Individual results vary and these statements have not been evaluated to diagnose or treat any condition.